The cells are slower-growing, and look more like normal breast cells. Grade 2 or moderately differentiated (score 6, 7). The cells are growing at a speed of and look like cells somewhere between grades 1 and 3. Grade 3 or poorly differentiated (score 8, 9). The cancer cells look very different from normal cells and will probably grow and spread Breast cancer is the most common malignant tumor in females. While most carcinomas are categorized as invasive carcinoma, no special type (NST), a diverse group of tumors with distinct pathologic and clinical features is also recognized, ranging in incidence from relatively more common to rare. Abstract. Invasive breast carcinoma of no special type (IBC-NST) with medullary pattern is an uncommon histologic type of invasive breast carcinoma. It is associated with high-grade, poorly differentiated tumor cells that form large sheets of irregular confluent tumor cells associated with a prominent lymphocytic infiltrate. Most invasive breast cancers have no special features and are classed as No Special Type (NST) or not otherwise specified (NOS). Between 70 and 80 out of 100 (between 70 and 80%) breast cancers are this type. Special type means that when the doctor looks at the cancer cells under a microscope the cells have particular features. Introduction. Classification of breast neoplasms has been constantly evolving. Invasive carcinomas of no special type (invasive ductal carcinoma) and relatively common special types (such as lobular, mucinous and micropapillary carcinomas, to name but a few) remain constituting most breast malignancies. The purpose of the present study was to investigate if the vimentin expression status might serve as a significant predictor of outcomes in patients with invasive breast carcinoma of no special type (IBC-NST) and to investigate, by comprehensive RNA sequencing analyses, the mechanisms involved in the heightened malignant potential of vimentin Invasive breast carcinoma of no special type, previously known as invasive ductal carcinoma, not otherwise specified, is the most common type of breast cancer (70-80%) 5. It is an infiltrating and malignant proliferation of neoplastic cells in the breast tissues. If there has been prior neoadjuvant treatment and no invasive carcinoma is present, the cancer is classified as ypTis if there is residual DCIS and ypT0 if there is no remaining carcinoma. A protocol is not required if no cancer is present in the specimen. bfOVVq3.

invasive carcinoma of no special type